Most favorable area of target reservoirs in Fudong area of Junggar Basin has been predicted only by means of high-resolution sequence stratigraphy or diagenesis evolution, which could not satisfy precise exploration requirement. However, the coupling of high-resolution sequence stratigraphy and diagenesis evolution can not only divide thin sand layer, but also supply diagenetic anisotropy in thin sand layer, all of which has poster significance in the exploration of hydrocarbons. Therefore, on the basis of previous research on sequence stratigraphy, the characteristics and evolution of diagenesis in a high-resolution sequence stratigraphical framework of reservoir sand in the Toutunhe Formation in the Fudong slope area are analyzed by using drilling and logging data as well as extensive experimental data in this work. The results indicate that the sequence of the interface is able to control the contact relationship between grains, the content of rock fragments, the content of feldspar, the content of cements and the transformation between clay minerals. Four structural types of the short-term cycle exist, and this research discusses the character of diagenesis within different structural types of short-term cycles. This research reflects that sequence stratigraphy has a certain relationship with diagenesis. The analysis of diagenesis evolution in cycles with different structural types is able to provide guidance on how to find productive reservoirs in small area regions.